Synthesis of Chiral Pyrrolidine Derivatives from (S)-Pyroglutamic Acid. II. 4-(Hydroxymethyl)-3-azabicyclo[3.1.0]hexan-2-ones and 5,5-Disubstituted 2-Pyrrolidinones

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概要

• 論文の詳細を見る

• The chiral pyrrolidine derivatives, 4-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-2-ones (10 and 11) and 5,5-disubstituted 2-pyrrolidinones (20,21 and 22), were synthesized starting from (S)-pyroglutamic acid and absolute configuration determination was made based on the ^1H-NMR spectra of the bicyclic lactam intermediates.

• 公益社団法人日本薬学会の論文
• 1997-01-15

著者

• Imai T

  Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn

• Imai Tomoko

  Tokyo University Of Pharmacy And Life Science School Of Pharmacy

• Nagasaka T

  Tokyo University Of Pharmacy And Life Science School Of Pharmacy

• Nagasaka Tatsuo

  Tokyo University Of Pharmacy And Life Science College Of Pharmacy

関連論文

• Synthesis of Chiral Pyrrolidine Derivatives from (S)-Pyroglutamic Acid. I : 7-Substituted (2R, 5S)-2-Aryl-1-aza-3-oxabicyclo[3.3.0]octan-8-ones, 7-Substituted (2R, 5S)-2-Aryl-1-aza-3-oxabicyclo[3.3.0]oct-6-en-8-ones and 3-Substituted (S)-5-(Hydroxymethyl)
• Synthesis of Chiral Pyrrolidine Derivatives from (S)-Pyroglutamic Acid. II. 4-(Hydroxymethyl)-3-azabicyclo[3.1.0]hexan-2-ones and 5,5-Disubstituted 2-Pyrrolidinones

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