Antioxidant Activity of Novel Indole Derivatives and Protection of the Myocardial Damage in Rabbits
スポンサーリンク
概要
- 論文の詳細を見る
Novel indole derivatives containing a triazole moiety(1a-d, 2a-c)were synthesized as lead compounds with intersting pharmacological profiles. Their antioxidant activity was investigated on in vitro non-enzymatic rat hepatic microsomal lipid peroxidation. All compounds showed significant effect in the above assay. The effect depended mainly on the attachment position of the triazole moiety on the indole nucleus. The most potent antioxidant derivatives 1a, 1c and 1d were tested for their protective ability against the oxdative damage of the myocardium after ischemia-reperfusion, in male rabbits which were subjected to 30 min regional ischemia followed by reperfusion. The tested antioxidant compounds 1a, 1c and 1d were continuously infused for 30 min starting at 10th min of ischemia and lasted at 10th min of reperfusion. The concentration of malondialdehyde(MDA, a marker of lipid peroxidation)and hemodynamic parameters(blood pressure and heart rate)were measured in the baseline, at 20th min of the sustained ischemia, 1st and 20th min of reperfusion. It was found that the examined compounds 1a, 1c and 1d reduced significantly the level of MDA in rabbits under ischemia-reperfusion and proved to be promising substances for further evaluation of anti-ischemic properties.
- 公益社団法人日本薬学会の論文
- 2002-02-01
著者
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Kremastinos Dimitrios
Greece Second Department Of Cardiology Onassis Cardiac Surgery Center
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ANDREADOU Ioanna
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens
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TASOULI Androniki
Greece, Second Department of Cardiology, Onassis Cardiac Surgery Center
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BOFILIS Elias
Greece, Second Department of Cardiology, Onassis Cardiac Surgery Center
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CHRYSSELIS Michael
Greece, and Department of Medicinal Chemistry, School of Pharmacy, Aristotelian University of Thessa
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REKKA Eleni
Greece, and Department of Medicinal Chemistry, School of Pharmacy, Aristotelian University of Thessa
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TSANTILI-KAKOULIDOU Anna
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens
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ILIODROMITIS Efstathios
Greece, Second Department of Cardiology, Onassis Cardiac Surgery Center
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SIATRA Theodora
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens
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Siatra Theodora
Department Of Pharmaceutical Chemistry School Of Pharmacy University Of Athens
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Andreadou I
Department Of Pharmaceutical Chemistry School Of Pharmacy University Of Athens
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Andreadou Ioanna
Department Of Pharmaceutical Chemistry University Of Athens School Of Pharmacy
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Bofilis Elias
Greece Second Department Of Cardiology Onassis Cardiac Surgery Center
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Rekka E
Greece And Department Of Medicinal Chemistry School Of Pharmacy Aristotelian University Of Thessalon
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Iliodromitis Efstathios
Greece Second Department Of Cardiology Onassis Cardiac Surgery Center
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Tasouli Androniki
Greece Second Department Of Cardiology Onassis Cardiac Surgery Center
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Tsantili-kakoulidou Anna
Department Of Pharmaceutical Chemistry School Of Pharmacy University Of Athens
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Andreadou Ioanna
Department Of Pharmaceutical Chemistry School Of Pharmacy University Of Athens
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Chrysselis M
Greece And Department Of Medicinal Chemistry School Of Pharmacy Aristotelian University Of Thessaloniki
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- Antioxidant Activity of Novel Indole Derivatives and Protection of the Myocardial Damage in Rabbits
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