Intercalation Compounds of Layered Materials for Drug Delivery Use. II. Diclofenac Sodium

スポンサーリンク

概要

• 論文の詳細を見る

• Intercalation compounds of ternary layered inorganic materials, synthetic mica(Na-TSM), with diclofenac sodium(DFS)and its drug release characteristics were investigated. Hygroscopic DFS was selected as a model drug to verify the anti-humidity and anti-oxidation of the intercalation compounds. Na-TSM powder was first mixed with the reduced-type phosphatidylcholine(H-PC)solution of chloroform or ethanol. DFS was then mixed with these solutions and heated at 37℃ to prepare the ternary Na-TSM/H-PC/DFS compound. A remarkable phenomenon was observed in the drug release study. The net amount of DFS from the DFS powder decreased apparently after 20min aristing from the decomposition of DFS in acidic medium. On the other hand, the net amount of the released DFS from the intercalation compound was invariant. Thermal analyses study indicated that DFS powder was hygroscopic and a significant endothermic peak was observed accompanied by a large weight loss due to the dehydration of absorbed water from 40 to 90℃. On the other hand, no significant dehydration reaction was observed in the intercalation compounds even in the sample stored under humid conditions. The present results indicated that the ternary intercalation compound was resistant to acid in addition to anti-humidity.

• 公益社団法人日本薬学会の論文
• 2001-08-01

著者

• KANZAKI Yasushi

  Laboratory of Analytical Chemistry Showa College of Pharmaceutical Sciences

• 神崎 〓

  Showa Pharmaceutical University

• SUZUKI Noriko

  Showa Pharmaceutical University

• Kanzaki Y

  Showa Pharmaceutical University

• Suzuki Noriko

  Laboratory For Biopolymer Physice Department Of Polymer Science And Engineering Kyoto Institute Of T

• NAKAMURA Yasuaki

  Laboratory of Analytical Chemistry Showa Pharmaceutical University

• WATANABE Yoshiteru

  Laboratory of Pharmaceutics Showa Pharmaceutical University

関連論文

• Properties of Blocking and Non-blocking Monoclonal Antibodies Specific for Human Macrophage Galactose-type C-type Lectin (MGL/ClecSF10A/CD301)
• Drug Release Characteristics of Ternary Mica/Phosphatidylcholine/Drug Intercalation Compounds
• Local Anesthetic Cream Prepared from Lidocaine-Tetracaine Eutectic Mixture
• P46.混合層状無機化合物のセシウムイオンに対するイオン交換特性 : 高pH領域における考察(ポスターセッション,第50回粘土科学討論会発表論文抄録)
• P46 混合層状無機化合物のセシウムイオンに対するイオン交換特性 : 高pH領域における考察
• 電気分解・電気透析による微生物の殺菌
• Human macrophage lectin specific for galactose/N-acetylgalactosamine is a marker for cells at an intermediate stage in their differentiation from monocytes into macrophages
• 層状無機化合物への酵素のインターカレーション : 種々の方法を用いたインターカレーション
• Relation between Drug-Induced Taste Disorder and Chelating Behavior with Zinc Ion : Statistical Approach to the Drug-Induced Taste Disorder, Part II
• Statistical Approach to the Drug-Induced Taste Disorders Based on Zinc Chelating Ability
• Texture Change of Beef and Salmon Meats Caused by Refrigeration and Use of Pulse NMR as an Index of Taste
• イオン交換樹脂を用いた電気透析によるバクテリオファージの不活化
• カーボン繊維電極を用いた電解殺菌
• Pulse NMR Study of Refrigerated Cooked Rice and Comparison with Physicochemical Properties
• Chemical States and Lattice Dynamics of α-Diimine Fe^ Complexes Intercalated into γ-Zirconium Phosphate
• パラジウム被覆カーボン繊維電極を用いた微生物の電解殺菌
• Kinetics of the Peptide Formation Catalyzed by Tehrmolysin in a Homogeneous Aqueous-Organic System
• Intercalation of n-Alkylamines in Proton-Type Layered Titanium(IV) Oxide
• 種々の遷移金属酸化物に取り込まれたリチウムイオンに関する固体NMRによる研究
• 電解機能水と電解殺菌
• 電解機能水
• 研究・技術開発と起業
• 電解機能水の現状とその可能性
• 巻頭言「電気化学とことば」を振り返って
• 「電解機能水」と医療
• P63 NMR法によるNa型合成雲母の構造に関する研究
• P46 Na型合成雲母のアルカリ金属に対するイオン交換特性 : 水和数による考察
• 4-2 土壌および粘土鉱物によるイオン交換特性(4.土壌物理化学・鉱物)
• Ion-Exchange Reaction of Cs^+ Selective Layered γ-Titanium and γ-Zirconium Phosphates
• イオン交換膜電気透析法における水解離により生成したH+およびOH-イオンの殺菌効果
• Intercalation Compound of Diclofenac Sodium with Layered Inorganic Compounds as a New Drug Material
• Influence of Admixture with Urea Ointment and White Petrolatum on the Penetration of Corticosteroids into Yucatan Micropig Skin
• Intercalation Compounds of Layered Materials for Drug Delivery Use. II. Diclofenac Sodium
• The Ion-Exchange Property of Some Layered Inorganic Materials with Potassium Ion Rubidium Ion and Cesium Ion, and Selective Cesium Ion-Exchange of Synthetic Mica
• Interfering Effect for the Cesium Ion-Exchange Property of Sodium Difluorotetrasilicate and Sodium Taeniolite by Alkaline-Earth Metal Ions
• Intercalation Compounds of Layered Titanium Phosphate for Drug Delivery Use
• Solid NMR Study of Lithium Ions Accommodated in Various Transition Metal Oxides
• Electrochemical Disinfection Using Palladium Coated Carbon Cloth Electrodes III : Potential Method for Endoscope Deterging
• パラジウム被覆炭素繊維電極を用いた電解殺菌？内視鏡洗浄を指向した殺菌

もっと見る 閉じる

スポンサーリンク