Preparation of (Cyanomethylene) trimethylphosphorane as a New Mitsunobu-Type Reagent

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概要

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• (Cyanomethylene) trimethylphosphorane (CMMP) mediates Mitsunobu-type reactions, which are a versatile method for the alkylation of various nueleophiles (HA) with alcohols (ROH) to give RA. CMMP is quite effective for the reaction of carbon nueleophiles whose pK_a value are higher than 13. CMMP, which is very sensitive to air and moisture, was synthesized in two steps starting from chloroacetonitrile.

• 公益社団法人日本薬学会の論文
• 2003-04-01

著者

• TSUNODA Tetsuto

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Sakamoto I

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• KAKU Hiroto

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• SAKAMOTO Izumi

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Tsunoda Tetsuto

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Kaku H

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Kaku Hiroto

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

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