Role of Metallothionein in the Cell Cycle : Protection against the Retardation of Cell Proliferation by Endogenous Reactive Oxygen Species
スポンサーリンク
概要
- 論文の詳細を見る
The growth rate of metallothionein (MT)-null (MT-/-) cells was significantly lower than that of wild-type (MT+/+) cells, the cell cycle being arrested at the G_2/M phase in MT-/- cells and endogenous reactive oxygen species (ROS) accumulating with the progress of the cell cycle. Exogenous ROS generated on treatment with H_2O_2 arrested the cell cycle of MT-/- cells at the G_2/M phase more severely than that of MT+/+ cells. These observations suggest that MT maintains the normal cell cycle as an antioxidant against excessive endogenous ROS that are generated synchronously with the cell cycle and disturb the normal cell cycle.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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Ogra Y
Graduate School Of Pharmaceutical Sciences Chiba University
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Ogra Yasumitsu
Graduate School Of Pharmaceutical Sciences Chiba University
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Suzuki Kazuo
Graduate School of Agricultural and Life Sciences, The University of Tokyo
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Suzuki K
Graduate School Of Pharmaceutical Sciences Chiba University
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Takahashi Yukihisa
Graduate School of Pharmaceutical Sciences, Chiba University
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Ibata Kenji
Graduate School of Pharmaceutical Sciences, Chiba University
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Ibata Kenji
Graduate School Of Pharmaceutical Sciences Chiba University
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Takahashi Yukihisa
Graduate School Of Pharmaceutical Sciences Chiba University
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Suzuki Kazuo
Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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SUZUKI KAZUO
Faculty of Pharmaceutical Sciences, Chiba University
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