Gambogic Acid Induces Apoptosis and Regulates Expressions of Bax and Bcl-2 Protein in Human Gastric Carcinoma MGC-803 Cells(Pharmacology)

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概要

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• The selective induction of apoptosis of gambogic acid (GA) on MGC-803 cells and its probable molecular mechanism were studied. GA greatly inhibited (24, 48, 72 h) the growth of MGC-803 cells (by MTT); the IC_<50> value was 0.96μg/ml at 48h. Meanwhile, no influence was observed on body weight, number of WBC (white blood cells) in blood or karyote in marrow of rats after GA was injected intravenously. We conclude that GA does not affect normal cells, but that it can induce apoptosis in tumor cells selectively and there were marked morphological changes. A great quantity of apoptotic cells and increasing G_2/M phase cells were observed by flow cytometry, and a significant percentage of early apoptotic cells were observed by Annexin-V/PI double staining assay. The increase of bax gene and the decrease of bc1-2 gene expressions were detected by immunohistochemistry. Activation of bax and suppression of bc1-2 may contribute to the apoptosis mechanism.

• 公益社団法人日本薬学会の論文
• 2004-07-01

著者

• You Qi-dong

  Jiangsu Key Lab. Of Carcinogenesis And Intervention (china Pharmaceutical University) People's

• You Qi-dong

  Jiangsu Key Laboratory Of Carcinogenesis And Intervention China Pharmaceutical University

• YOU Qi-Dong

  Department of Medicinal Chemistry, China Pharmaceutical University

• ZHAO Li

  Department of Physiology, China Pharmaceutical University

• GU Hong-Yan

  Department of Physiology, China Pharmaceutical University

• Gu Hong-yan

  中華人民共和国

• Gu Hong-yan

  Jiangsu Key Laboratory Of Carcinogenesis And Intervention China Pharmaceutical University

• Zhao Li

  中華人民共和国

• Zhao Li

  Department Of Epidemiology Tongliao Center For Disease Prevention And Control

• Guo Q‐l

  Jiangsu Key Laboratory Of Carcinogenesis And Intervention China Pharmaceutical University

• Guo Qing-long

  Department Of Physiology No. 24 Tong Jia Xiang China Pharmaceutical University

• Zhao L

  Saitama Univ. Saitama

• Zhao Li

  Department Of Endocrinology Metabolism And Nephrology Kochi Medical School Kochi University

• Zhao Li

  Faculty Of Information And Computer Sciences Toyohashi University Of Technology

• Wu Zhao-Qiu

  Department of Physiology, China Pharmaceutical University

• Wu Z‐q

  Department Of Physiology China Pharmaceutical University

• Wu Zhao-qiu

  Department Of Physiology No. 24 Tong Jia Xiang China Pharmaceutical University

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