Antinociceptive Profile of 2-Phenylselenenyl-1,8-cineole in Mice(Pharmacology)
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概要
- 論文の詳細を見る
2-Phenylselenenyl-l,8-cineole (PSC) increased both the pentobarbital-induced sleeping time and the reaction time (up to 2 h) in the tail immersion method. PSC also caused dose-dependent inhibition of acetic acid induced writhing with maximum inhibition of 93.4% and was approximately 8.5-fold more potent than 1,8-cineole. These findings show that PSC presents sedative effect and significant antinociceptive activity.
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
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Sousa Damiao
Laboratorio De Quimica Bio-organica Departamento De Quimica Universidade Federal De Sao Carlos
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RAPHAEL Ellen
Laboratorio de Quimica Bio-Organica, Departamento de Quimica, Universidade Federal de Sao Carlos
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BROCKSOM Ursula
Laboratorio de Quimica Bio-Organica, Departamento de Quimica, Universidade Federal de Sao Carlos
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BROCKSOM Timothy
Laboratorio de Quimica Bio-Organica, Departamento de Quimica, Universidade Federal de Sao Carlos
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Raphael Ellen
Laboratorio De Quimica Bio-organica Departamento De Quimica Universidade Federal De Sao Carlos
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Brocksom Ursula
Laboratorio De Quimica Bio-organica Departamento De Quimica Universidade Federal De Sao Carlos
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Brocksom Timothy
Laboratorio De Quimica Bio-organica Departamento De Quimica Universidade Federal De Sao Carlos
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- Antinociceptive Profile of 2-Phenylselenenyl-1,8-cineole in Mice(Pharmacology)