Dentin Is Dissolved by High Concentrations of L-Ascorbic Acid 2-[3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl-hydrogen Phosphate] Potassium Salt with or without Hydrogen Peroxide(Toxicology)

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概要

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• L-Ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl-hydrogen phosphate] potassium salt (EPC-K_1) is a conjugate of vitamin C and vitamin E that is water-soluble and stable at room temperature. EPC-K, has been developed as a hydroxyl radical (・OH) scavenger and antioxidant. In a previous tooth whitening experiment, it was accidentally found that tooth (dentin) blocks were dissolved by EPC-K_1 with H_2O_2. In the current study, high concentrations of EPC-K_1 (2.5, 25 HIM) with 3% H2O2 dissolved and caused the collapse of dentin blocks. Similar concentrations of EPC-K_1 without 3% H_2O_2, however, dissolved the dentin blocks without collapse over a 3-week period. In these cases, a -OH-like signal was detected using an ESR spin-trapping method. The volume of calcium in solution (including the dentin block) increased on the addition of EPC-K_1 in a concentration-dependent manner. In addition, the calcium: phosphorus ratio changed from 2 :1 in sound dentin to 1:2 in the collapsed dentin block. High concentrations of EPC-K_1 are therefore considered to have calcium chelating and dentin dissolving activity. The dentin dissolving activity was enhanced when EPC-K_1 was used with H_2O_2. EPC-K_1 had no protective effect when used in tooth whitening with H_2O_2.

• 公益社団法人日本薬学会の論文
• 2004-06-01

著者

• Tsujimoto Y

  Department Of Endodontics Nihon University School Of Dentistry At Matsudo

• KOZUKA Masahiro

  Research Institute of Oral Science, Department of Endodontics, Nihon University School of Dentistry

• TSUJIMOTO Yasuhisa

  Research Institute of Oral Science, Department of Endodontics, Nihon University School of Dentistry

• Kozuka Masahiro

  Research Institute Of Oral Science Department Of Endodontics Nihon University School Of Dentistry At

関連論文

• Stimulatory Effects of Hydroxyl Radical Generation by Ga-Al-As Laser Irradiation on Mineralization Ability of Human Dental Pulp Cells(Molecular and Cell Biology)
• Dentin Is Dissolved by High Concentrations of L-Ascorbic Acid 2-[3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl-hydrogen Phosphate] Potassium Salt with or without Hydrogen Peroxide(Toxicology)

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