Biology of N-Methylpyrrole-N-methylimidazole Hairpin Polyamide (Biological and Pharmaceutical Aspects of Nucleic Acids Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Chemical substances that can recognize and bind DNA in a sequence-specific manner have enormous importance in modern biology and medicine. When covalently linked, hairpin polyamides made up of N-methylpyrrole (Py) and N-methylimidazole (Im) can bind to DNA in a sequence-specific manner. An Im opposite a Py recognizes and binds G : C from C : G, whereas a Py opposite an Im recognizes and binds to C:G. A Py-Py pair degenerately binds to T : A or A : T, whereas a hydroxypyrrole opposite a Py recognizes and binds to T : A from A:T, and vice versa. A variant in this recognition is the β-alanine (β-ala-β-ala) pair, which also degenerately binds to A : T or T : A. The hairpin polyamides are cell permeable and bind to DNA at nanomolar concentrations, with binding coefficients similar to those of transcription factors. This review comprehensively discusses the current literature on using the sequence-specific recognition ability of the polyamides to study various DNA-protein interactions.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
-
Sugiyama Hiroshi
Institute of Materials Structure Science, High Energy Accelerator Research Organization, KEK
-
Murty Musti
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
-
Sugiyama Hiroshi
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University:department Of Chemi
-
Sugiyama Hiroshi
Institute For Integrated Cell-material Sciences (icems) Kyoto University
関連論文
- Time-Delayed Interferometry with Nuclear Resonant Scattering of Synchrotron Radiation
- Transcriptional Induction of Acyl-CoA Oxidase by Dehydroepiandrosterone Sulfate in Cultured Rat Hepatocytes
- INDUCTION OF PEROXISOME PROLIFERATION AND PEROXISOMAL β-OXIDATION BY DEHYDROEPIANDROSTERONE
- Fluorescent X-ray imaging with synchrotron radiation for the evaluation of probes for biomedical functions : A pilot study on 4-bromo-DL-phenylalanine for cancer detection in mice
- X-Ray Optics 'Owl' and 'Trinity'
- X-Ray Optics for Observing Dark-Field and Bright-Field Refraction-Contrast Images : Instrumentation, Measurement, and Fabrication Technology
- A New Optics for Dark-Field Imaging in X-Ray Region 'Owl' : Instrumentation, Measurement, and Fabrication Technology
- An X-Ray Trichrome Imaging 'Trinity' : Absorption, Phase-Interference and Angle-Resolved Contrast : Instrumentation, Measurement, and Fabrication Technology
- Nondestructive Visual Search for Fossils in Rock Using X-Ray Interferometry Imaging
- 26aYA-12 Design and Performance of High Resolution Monolithic Monochromators
- Temporal Mossbauer Absorber Thickness Effect Demonstrated Using Synchrotron Radiation
- Biology of N-Methylpyrrole-N-methylimidazole Hairpin Polyamide (Biological and Pharmaceutical Aspects of Nucleic Acids Chemistry)
- Molecular mechanism of GG-specific photooxidation of DNA
- 1M1524 DNA-kinesinハイブリッド・ナノマシンの構築(分子モーター2,第49回日本生物物理学会年会)