The Effect of Chondroitin Sulfate against CCl_4-Induced Hepatotoxicity
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概要
- 論文の詳細を見る
This study was conducted to develop a new biomaterial to be used for an antioxidative drug. In this study, the hepatoprotective effect of chondroitin sulfate (CS) (100mg/kg and 200mg/kg body weight) was investigated at the antioxidative enzyme levels of liver total homogenate and mitochondria fraction. And the carbone tetrachloride (CCI_4)-induced rats were used as hepatotoxic models. The CCI_4 induced rat has been widely used as a hepatotoxic model due to its practicality, convenience and cost effectiveness since the generation of free oxygen radicals by CC1_4 injection was proposed as an important causative agent of hepatotoxicity. Malondialdehyde (MDA) levels were determined as well as the activities of superoxide dismutase (SOD), catalase (CAT), reduced-glutathione (GSH), oxidized-glutathione (GSSG) and glutathione peroxidase (GP_x) in the liver. In addition, histopathology of liver tissue was investigated. Liver antioxidative enzyme activity was elevated while MDA con centration was decreased in all CS treated animals. The results demonstrated that CS protected oxidative stress in a dose dependent manner. Moreover, inflammation and cirrhosis in liver tissue of CS treated group were significantly decreased. It gave us an impression that CS might be a radical scavenger.
- 公益社団法人日本薬学会の論文
- 2003-05-01
著者
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Lee Jin
Department of Internal Medicine, Ewha Womans University School of Medicine and Ewha Medical Research
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HA Bae
Department of New Material Chemistry and Biotechnology, Silla University
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Lee J
Dep. Of Bioscience And Biotechnology Silla Univ.
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Ha Bae
Department Of Bioscience And Biotechnology Silla University
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Lee Jin
Department Of Biology Inha University
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LEE Jin
Department of Biochemistry, College of Medicine, Inje University
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Lee Jin
Department of Anatomy and Cell Biology, Collage of Medicine, Hanyang University
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