Characteristic Patterns of VEGF, Integrins, ERα and HER2 Immunoreactivity Suggest Two Tumor Cell Populations in DMBA-Induced Rat Mammary Tumor
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概要
- 論文の詳細を見る
Recent evidence has shown that certain tumors have characteristic cell populations related to tumor progression. Therefore, we investigated tumor cell populations in 7, 12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumor, an established estrogen-sensitive angiogenic tumor model. The tumors pathologically identified as invasive ductal carcinoma were immunostained using antibodies against the following various molecules : vascular endothelial growth factor (VEGF), integrins, estrogen receptor alpha (ERα), human epidermal growth factor receptor-2 (HER2), p27, and laminin, all of which are known to be related to tumor progression, proliferation and/or prognosis. The basal layer, the outermost layer of tumor lobules facing the basement membrane, was mainly VEGF and integrin (α3, α6, β1) positive. In contrast, the inner layer, the internal cell layers of the tumor lobules, was mainly ERα and HER2 positive. The p27-positive rate in the inner layer was similarly low to that in the basal layer, suggesting a similar high proliferative potency between these layers. Laminin was positive in the basement membrane surrounding the tumor lobules. These results suggest that the tumor lobules consist of at least two cell populations, the basal and inner layers, with respect to the expression of VEGF, integrins, ERα and HER2; and that these cell populations may have distinct functions in the pathophysiology of this mammary tumor.
- 日本組織細胞化学会の論文
著者
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INOUE TAKAO
Division of Science and Technology for Energy Conversion, Graduate School of Natural Science and Tec
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Ohgi Shigetsugu
Division Of Organ Regeneration Surgery Department Of Surgery Faculty Of Medicine Tottori University
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KAIDOH Toshiyuki
Division of Morphological Analysis, Department of Functional, Morphological and Regulation Science,
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Kaidoh Toshiyuki
The Division Of Morphological Analysis Department Of Functional Morphological And Regulation Science
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Kaidoh Toshiyuki
Deparment Of Anatomy Faculty Of Medicine Tottori University
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Inoue Tomoko
The Division Of Morphological Analysis Department Of Functional Morphological And Regulation Science
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INOUE TOMOKO
Division of Organ Regeneration Surgery, Department of Surgery, Faculty of Medicine, Tottori Universi
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Kaidoh T
Department Of Anatomy Faculty Of Medicine Tottori University
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Inoue Takao
Division Of Morphological Analysis Department Of Functional Morphological And Regulatory Science Fac
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Inoue Takao
Division Of Morphological Analysis Department Of Functional Morphological And Regulatory Science Tot
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Kaidoh Toshiyuki
Division Of Morphological Analysis Department Of Functional Morphological And Regulatory Science Tot
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