心疾患における血中ミオシン軽鎖 I 測定の臨床的意義

概要

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Serum myosin light chain I (LCI) levels were quantitated serially using an immunoradiometric assay kit (myosin LI kit "Yamasa") in 60 patients with heart diseases including 43 cases of acute myocardial infarction and 13 cases of unstable angina. All but one case of acute myocardial infarctions showed elevated LCI values (>2.5ng/ml). In these cases, LCI began to increase after 4〜8 hours from the onset and continued at high levels for at least 7 days. In one case for whom PTCA was conducted very soon following time of onset, LCI was within normal limits in spite of a marked elevation of serum CPK. In 13 cases of unstable angina, 5 showed elevated LCI, suggesting myocardial necrosis to a slight degree. In case of myocarditis with severe heart failure, LCI was markedly elevated. Measurement of serum LCI would thus appear quite useful for detecting myocardial necrosis and assessing its severity.
社団法人日本放射線技術学会の論文
1992-12-01