米国における高エネルギー粒子線治療

概要

論文の詳細を見る
Based on the substantial accumulation of recent radiobiological improvements, high LET radiation using nuclear particles has been applied for clinical trials. High LET radiation has the properties of (1) improved dose distributions due to Bragg peak, and (2) reduced repair from sublethal damage and OER. In USA and Canada, neutrons, protons, pi-mesons and heavy particles are being used for clinical trials. Over 2,500 cases have been treated with neutrons until the end of 1981. The results are comparable to those of conventional photons, but not so good as those from Hammersmith Hospital neutron trial. Ocular melanomas are treated with protons at Harvard Cyclotron/MGH with excellent results (local control 93/95). These are attributable to excellent spatial dose distribution and prescise positioning, for protons are not considered as high LET. Pimeson treatment had been conducted at LAMPF from 1974 through 1981 with 230 clinical cases. However, mainly because of the budgetary and locational limitations, it is not operational to date. Radiotherapy of Helium ions and heavy particles are being conducted at Lawrence Berkeley Laboratory. Helium irradiation has yielded significant results, but further compilation and precise evaluation are still needed as to heavy particles. Advantage of high LET will probably be justified with the accumulation of biological and clinical data in the near future.
社団法人日本放射線技術学会の論文
1984-03-01