Endogenous Testosterone Controls Humoral Immunity in the Lizard, Chalcides ocellatus(Endocrinology)

概要

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Study of the correlation between endogenous blood levels of testosterone (TS) and the humoral immune response of male lizards, Chalcides ocellatus led to three major findings: 1) Long-term testosterone propionate (TP) treatment in "summer" induced an elevation of serum TS and complete abrogation of primary anti-rat erythrocytes (RRBC) antibody response similar to normal intact lizards during "spring"; 2) Bilateral orchidectomy of male lizards during "spring" showed increased response to RRBC and suggested that orchidectomy potentiated immunity and more particularly definite stimulation of humoral immunity; 3) Long-term TP treatment of orchidectomized lizards failed to suppress immune response to RRBC. Indeed, orchidectomized lizards given TP had response to RRBC similar to male intact controls. The results are discussed from the perspective of the role played by TS in mediating the seasonal rhythms that affect reptilian immunity.
社団法人日本動物学会の論文
1992-10-15