Seasonal Changes in Humoral Immunity and Blood Thyroxine Levels in the Toad, Bufo regularis(Endocrinology)

概要

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The present study was designed to explore the basis of seasonal changes in the humoral immune response of the toad, Bufo regularis. The results indicated that; (1) administration of 0.4 ml of 10% RRBC suspension during the breeding season and the time of burrowing for winter elicited a high liter of antibody (Ab) and vigorous rosette-forming cell (RFC) resoponse. In contrast, during summer active life period and hibernation, immune response was slow with a low titer of Ab and minimal number of RFC; (2) cold-acclimated toads (8-10℃; 3 weeks) provided a considerable amount of serum Ab in response to primary immunization with RRBC; despite that the magnitude and the kinetic of the response were significantly different from those of control toads; (3) fluctuation in thyroxine (T_4) levels was in direct correlation with the immunological indices recorded for adult toads during the different periods of the year. Our results suggest that endogenous T_4 levels generally trigger B. regularis immune system with low levels causing a significant inhibition and with high levels causing a significant stimulation of humoral immune response.
社団法人日本動物学会の論文
1992-04-15