Appearance of a Nuclear Histone H1 Kinase at the Start of DNA Synthesis of Regenerating Rat Liver(Biochemistry)

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概要

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• Phosphorylation of histone H1 and elevation of nuclear protein kinase activity occur at the start of DNA synthesis during regeneration of rat liver. X ray irradiation prior to partial hepatectomy depressed both elevation of the nuclear protein kinase activity and DNA synthesis. Thus, the protein kinase seemed to play a role in the start of DNA synthesis, but the property of the enzyme was not well characterized. The nuclear protein kinase activity was measured with casein or histone H1 as substrate. A protein kinase activity specific for histone H1 was found in the extract from the regenerating liver nuclei, but not that from the irradiated and partially hepatectomized liver nuclei. On the other hand, casein kinase activity was found in the extract from the regenerating liver irrespoctive of prior X ray irradiation. Gel filtration chromatography of the nuclear extract revealed the presence of the histone H1 kinase and two casein kinases in the regenerating liver. Histone H1 kinase was observed in the regenerating liver, but not in the non-hepatectomized nor the irradiated and hepatectomized liver. Two casein kinases were found in the non-hepatectomized liver and partial hepatectomy with or without prior X irradiation induced a little increase in the activites. The present results indicate that appearance of the nuclear histone H1 kinase activity is required for phosphorylation of histone H1 and the start of DNA synthesis in the regenerating liver.

• 社団法人日本動物学会の論文
• 1992-10-15

著者

• Asami Kouichi

  Division Of Biology National Institute Of Radiological Sciences : (present Address)department Of Bio

• Asami Kouichi

  Division Of Biology National Institute Of Radiological Sciences

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