Homeostatic Integration of Stem Cell Dynamics during Palleal Budding of Ascidians

概要

論文の詳細を見る
A palleal bud of botryllid and polystyelid ascidians consists of a double-walled vesicle, of which the inner epithelium and hemoblasts in the blood are stem cells that play a key role in bud morphogenesis. Morphogenesis begins with the formation of pharyngeal and gut rudiments that define the future anterior and posterior ends of the body, respectively. In Polyandrocarpa misakiensis, it follows the mitotic cell activation of both kinds of stem cells and the epithelial transformation of hemoblasts. Those behaviors of stem cells are influenced both by humoral factor(s) from the parent and by short- and long-range cell signallings based on parental positional information, enabling homeostatic integration of primary body patterning of buds. Such morphogenetic events involve granular exocytosis of bioactive substances such as a galactose-binding, 14kDa lectin, that forms the extracellular matrix in the mesenchymal space during the earliest stage of bud development. We suggest that in budding of ascidians homeostatic cell and tissue interactions for pattern formation depend partially, at least, on the spatio-temoorally regulated exocytosis of so-called autacoids.
社団法人日本動物学会の論文
1991-02-15