Plasticity in Development of the Central Nervous System

概要

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Development of the central nervous system analyzed in quail-chick chimera is re-viewed. The fate map of the brain vesicles has been studied. Posterior mesencephalon is shown to differentiate into the anterior cerebellum. Metencephalon differentiates into the posterior cerebellum. On the cytodifferentiation of the cerebellum, challenging results to the classical hypothesis have been obtained. Heterotopic transplantations of the brain vesicles show that the brain vesicles have limited capacity to change their fate. Alar plate of the prosencephalon can differentiate into the optic tectum when ransplanted into the mesencephalon. Rostral part of the mesencephalon has capacity to differentiate into the cerebellum, and rostral part of the metencephalon can differentiate into the optic tectum. Caudal part of the mesencephalon and metencephalon did not change their fate. Rotation of the rostrocaudal axis of the tectum anlage at around 10 somite stage shows that rostrocaudal axis of the tectum is not determined at that stage. The rotated tectum is regulated of its rostrocaudal axis, and later cytoarchitectonic development and retinotectal map formation proceed according to the host axis. Rostrocaudal specificity of the optic tectum may be determined through interactions with surrounding tissue, and well organized retinotectal map may be achieved in a retinotopic manner.
社団法人日本動物学会の論文
1991-02-15