Effect of Somatostatins and Insulin on Blood Glucose Levels of Larvae and Metamorphosing Landlocked Sea Lamprey, Petromyzon marinus(Endocrinology)

スポンサーリンク

概要

• 論文の詳細を見る

• We examined the effects of insulin (INS) and somatostatin 14 (SS-14) on glycemic regulation in larval and metamorphosing landlocked sea lamprey, Petromyzon marinus. Animals were injected intraperitoneally with either (Experiment 1) saline (0.6%), somatostatin-14 (SS-14 ; 50 or 500 ng/g body weight), insulin (INS ; 10 or 100 ng/g body weight), or alloxan (20 or 200μg/g body weight), or with (Experiment 2) normal rabbit serum, anti-SS-14, anti-lamprey SS-34 or anti-lamprey INS. Somatostatin-14 (500 ng/g) increased plasma glucose levels in larvae. Injection of anti-SS-14 and anti-lamprey SS-34 resulted in hypoglycemia compared to the controls. Insulin (100 ng/g) resulted in hypoglycemia in both larvae and stage 6 metamorphosing lamrpey. Acute insufficiency of lamprey INS in larvae treated with anti-lamprey INS elevated plasma glucose levels. Similarly, alloxan (200μg/g, a cytotoxin of insulin-secreting cells) resulted in hyperglycemia in larvae. These data indicate that SS-14 is hyperglycemic in sea lamprey, whereas INS is hypoglycemic, and suggest that the glucoregulatory roles of SS-14 and INS emerged early during the evolution of vertebrates.

• 社団法人日本動物学会の論文
• 2001-11-01

著者

• Sheridan M

  North Dakota State Univ. Nd Usa

• Holmes John

  Department Of Zoology Axelrod Institute Of Ichthyology University Of Guelph

• Kao Yung-Hsi

  Department of Life Science, College of Science, National Central University

• Sheridan Mark

  Department of Zoology and Regulatory Bioscience Center, North Dakota State University

• Youson John

  Department of Zoology and Division of Life Sciences, University of Toronto at Scarborough

• Youson J

  Department Of Zoology And Division Of Life Sciences University Of Toronto At Scarborough

• Holmes John

  Department Of Biostatistics And Epidemiology School Of Medicine University Of Pennsylvania

関連論文

• Use of photographs for the identification of pressure ulcers in elderly hospitalized patients : validity and reliability
• Effect of Alloxan and Insulin Immunoneutralization on Circulating Thyroid Hormone Levels in Larval Landlocked Sea Lampreys, Petromyzon Marinus(Endocrinology)
• Effect of Somatostatins and Insulin on Blood Glucose Levels of Larvae and Metamorphosing Landlocked Sea Lamprey, Petromyzon marinus(Endocrinology)
• Glucose-stimulated Somatostatin Gene Expression in the Brockmann Bodies of Rainbow Trout (Oncorhynchus mykiss) Results from Increased mRNA Transcription and not from Altered mRNA Stability(SHORT COMMUNICATON,Endocrinology)
• Previous Nutritional State and Glucose Modulate Glucagon-Mediated Hepatic Lipolysis in Rainbow Trout, Oncorhynchus mykiss(Physiology)

スポンサーリンク