Effect of Alloxan and Insulin Immunoneutralization on Circulating Thyroid Hormone Levels in Larval Landlocked Sea Lampreys, Petromyzon Marinus(Endocrinology)

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概要

• 論文の詳細を見る

• The effects of alloxan, an insulin (INS)-secreting cell toxin, and INS immunoneutralization on circulating levels of thyroid hormones (thyroxine, T_4; triiodothyronine, T_3) were examined in larval landlocked sea lampreys, Petromyzon marinus. Animals were injected intraperitoneally with either (Experiment 1) saline (0.6%) or alloxan (20 or 200μg/g body weight), or with (Experiment 2) normal rabbit serum or anti-lamprey INS. Alloxan (200μg/g) decreased plasma T_3, but not T_4, in larvae by about 45-80%. Three, six, or nine hr after acute immunoneutralization of lamprey INS with anti-lamprey INS, plasma T_3 levels decreased by 13-30%, relative to controls. These data indicate that INS deficiency can regulate the thyroid system of larval lampreys. There is some suggestion that INS may mediate the metamorphic processes by modulating thyroid hormone concentrations.

• 社団法人日本動物学会の論文
• 2003-05-25

著者

• Sheridan M

  North Dakota State Univ. Nd Usa

• Holmes John

  Department Of Zoology Axelrod Institute Of Ichthyology University Of Guelph

• Kao Yung-Hsi

  Department of Life Science, College of Science, National Central University

• Manzon Richard

  Department of Biology, University of Michigan

• Sheridan Mark

  Department of Zoology and Regulatory Bioscience Center, North Dakota State University

• Leatherland John

  Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph

• Youson John

  Department of Zoology and Division of Life Sciences, University of Toronto at Scarborough

• Youson J

  Department Of Zoology And Division Of Life Sciences University Of Toronto At Scarborough

• Manzon Richard

  Department Of Biology University Of Michigan

• Leatherland John

  Department Of Biomedical Sciences Ontario Veterinary College University Of Guelph

• Holmes John

  Department Of Biostatistics And Epidemiology School Of Medicine University Of Pennsylvania

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• Effect of Alloxan and Insulin Immunoneutralization on Circulating Thyroid Hormone Levels in Larval Landlocked Sea Lampreys, Petromyzon Marinus(Endocrinology)
• Effect of Somatostatins and Insulin on Blood Glucose Levels of Larvae and Metamorphosing Landlocked Sea Lamprey, Petromyzon marinus(Endocrinology)
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