Double-lmmunolabeling Studies of Glucocorticoid Receptors in Enkephalinergic Neurons of the Rat Spinal Cord(Neurobiology)

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Using double-immunolabeling, we attempted to localize the glucocorticoid receptor (GR) and methionine-enkephalin-octapeptide (ENK-8) in the rat spinal cord. The 2nd to 8th cervical segments were analyzed in intact and in colchicine-injected animals. GR immunoreactivity was detected in the nuclei of neurons in all segments, and was most intense in small neurons in the superficial layers (laminae 1-3) of the dorsal horn. Medium-sized neurons in laminae 4-6 and the reticular formation, as well as the large ventral horn neurons, all showed moderate immunoreactivity. Double-immunolabeling revealed that, in all regions examined except the ventral horn, some of the GR-positive neurons were also ENK-8-positive. These findings suggest that enkephalinergic neurons in the spinal cord may be regulated by glucocorticoids, each of which is presumably related to the neuronal antinociceptive mechanism in the dorsal horn.
社団法人日本動物学会の論文
2000-05-20