Possible Involvement of a Cell Cycle Control System Dependent on Nuclear Activities in Establishment of the Cell Division Interval in Early Xenopus Embryos(Developmental Biology)

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In early Xenopus embryos, continuous exposure of embryos to aphidicolin and inactivation of the nucleus by ultraviolet-irradiation induce prolongation of the cell division interval. The extent of prolongation of the cell division interval appears to depend on how heavily DMA replication is suppressed by the treatments. Embryos showing significantly prolonged cell division intervals tend to fail normal cell divisions, often forming abortive furrows. There appears to be a critical point for the extent of prolongation of the cell division interval at 30% that divides the success and failure of normal cell division. This percentage, 30%, coincides with that for the prolongation of the interval of oscillatory activities seen in enucleated eggs. The presence of an intact nucleus that can undergo DMA replication rescues normal cell divisions with normal intervals and a normal furrow. Histologically, the nucleus in embryos showing more than 30% prolongation of cell division intervals appears to fail DMA replication and remain unduplicated with a round morphology like the interphase nucleus. A number of unduplicated asters lacking chromosomes are found in these embryos. We conclude from these results that early Xenopus embryos, like late embryos, have a cell cycle control system that is affected by DMA replication and is involved in establishing the cell division interval.
社団法人日本動物学会の論文
1998-12-15