ICI 182,780 Stimulates the Growth of a Uterine Cell Line Derived from p53-Deficient Mice(Endocrinology)
スポンサーリンク
概要
- 論文の詳細を見る
UE8 is a uterine epithelial cell line established from p53-deficient fetal female mice. UE8 exhibits a typical epithelial morphology in culture and is strongly positive for cytokeratin, but negative for vimentin in immunocytochemistry. UE8 shows an active growth in a phenol red free 1:1 mixture of Dulbecco's modified Eagle's medium and Ham's nutrient mixture F-12 supplemented with 3% heat-inactivated and dextran-coated charcoal-treated fetal calf serum. Both immunocytochemistry and immunoblot analyses con-firmed that UE8 was negative for the estrogen receptor. Diethylstilbestroi added to the medium at concentrations between 10^<-6> and 10^<-8> M had no significant effect on the proliferative rate, and estradiol-17β at 10^<-6> M s slightly inhibitory. Unexpectedly, however, the "pure anti-estrogen" ICI 182,780 at 10^<-6> M significantly enhanced cell proliferation. This is the first observation that the "pure anti-estrogen" ICI 182,780 stimulates the growth of uterine epithelial cells without estrogen receptors.
- 社団法人日本動物学会の論文
- 1998-10-15
著者
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Hanazono Makoto
Department of Biological Engineering, Faculty of Basic Engineering, Tokyo University of Science
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Tomooka Yasuhiro
Department of Biological Engineering, Faculty of Basic Engineering, Tokyo University of Science
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Tomooka Y
Department Of Biologocal Science & Tecnology Tokyo University Of Science
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Tomooka Yasuhiro
Department Of Biological Engineering Faculty Of Basic Engineering Tokyo University Of Science
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Moro Kengo
Department of Biological Science and Technology, Science University of Tokyo
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Nakagawa Eriko
Department of Biological Science and Technology, Science University of Tokyo
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Nakagawa Eriko
Department Of Biological Science And Technology Science University Of Tokyo
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Hanazono M
Department Of Animal Science Teikyo University Of Science And Technology
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Hanazono Makoto
Department Of Animal Science Teikyo University Of Science And Technology
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Moro Kengo
Department Of Biological Science And Technology Science University Of Tokyo
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