Nucleolus Organizer Region Lateral Asymmetry Induced by BUdR Incorporation in Mouse Chromosomes(Cell Biology)

概要

論文の詳細を見る
Mouse lung cells from a primary culture were incubated with BUdR to obtain chromosomes with BT-TB, BB-TB and TB-TT chromatid constitution. After the silver staining, all of these differently BUdR-substituted chromosomes showed a marked increase of nucleolus organizer region lateral asymmetry (NLA) in which no silver dot or a smaller dot was present in the chromatid which contained more BUdR than did its sister chromatid. The NLA found in the BB-TB and TB-TT chromosomes mainly belonged to an extreme type of NLA in which only one silver dot was found almost exclusively in the TB- and TT-chromatid, respectively. The similarity in the extent of NLA occurred in the BB-TB and TB-TT chromosomes seemed to suggest that there may be some compensatory mechanism against the inhibitory effect of BUdR on the NOR activity.
社団法人日本動物学会の論文