Pteridine-Metabolizing Enzymes in Rat Erythrocytes during Development(Biochemistry)
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概要
- 論文の詳細を見る
The developmental pattern of sepiapterin reductase and dihydrofolate reductase, which are both involved in the final two steps of the metabolic pathway of tetrahydrobiopterin, were studied in blood cells of fetuses and neonates of rats, and in erythrocytes of young and adult rats. Levels of dihydrofolate reductase activity 60-fold higher and sepiapterin reductase 20% lower than those found in erythrocytes of adult rats were observed in fetal blood cells at 20 days of gestation. Reticulocytes from adult rats injected with phenylhydrazine showed a relatively higher level of sepiapterin reductase and a 20-fold higher level of dihydrofolate reductase activity compared with those in erythrocytes of adult rats. In blood cells of the fetal rat at 20 days of gestation, a similar amount of reduced pteridine and 80% activity of dihydropteridine reductase were also found compared with those in erythocytes of adult rats. Based on the above observations, we propose that biopterin metabolism in rat erythrocytes may be more stimulated during early development of the cell than in the mature period.
- 社団法人日本動物学会の論文
著者
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Katoh Setsuko
Department Of Biochemistry Josai Dental University
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SUEOKA TERUMI
Department of Biochemistry, Josai Dental University
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Sueoka Terumi
Department Of Biochemistry Josai Dental University
関連論文
- Cytochrome c-catalyzed Oxidation of Sepiapterin to 6-Lactylpterin
- ROLE OF TETRAHYDROBIOPTERIN ON PC12 CELLS PROLIFERATION(Biochemistry,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- CHANGES IN CELLULAR PROLIFERATION RATE OF TETRAHYDROBIOPTERIN DEFICIENT CELLS(Biochemistry,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- EFFECT OF TESTOSTERONE IN TETRAHYDROBIOPTERIN BIOSYNTHESIS OF THE HUMAN SALIVARY GLAND (HSG) CELLS(Biochemistry,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- CONTROL OF GENE EXPRESSION OF TETRAHYDROBIOPTERIN BIOSYNTHETIC ENZYMES IN HSG CELLS BY ANDROGEN(Biochemistry)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- EFFECT OF TRANSIENT DEFECT OF SEPIAPTERIN REDUCTASE EXPRESSION ON PC12 CELLS(Biochemistry)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Gene Expression of Enzymes Generating Tetrahydrobiopterin, an Essential Cofactor for NO Synthase, in Bone and Cultured Bone Cells
- Transient Activation of Dihydropteridine Reductase by Ca^-activated Proteolysis(Biochemistry)
- Pteridine-Metabolizing Enzymes in Rat Erythrocytes during Development(Biochemistry)
- BIOPTERIN AND 7-ISO BIOPTERIN SECRETED INTO SALIVA : Biochemistry : Abstracts of papers presented at the 60th Annual Meeting of the Zoological Society of Japan