位相差顯微鏡によるシロネズミの腹水肉腫におけるミトコンドリアの観察(予報)

概要

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The present investigation deals with the morphological changes of mitochondria in relation to the metabolic activity of tumor cells of the MTK-sarcoma III. The observations were carried out with living tumor cells under normal and treated conditions with the aid of phase optics. The mitochondria in living tumor cells are observed as gray or black, indistinctly outlined, and filamentous, rod- or dot-like bodies. They are generally inconstant in size and number in each cell. In general the filamentous and rod-like mitochondria are arranged in a rosette form in the cytoplasm, and those of dot-like shape scatter in the cytoplasm without definite orientation. The morphological features of mitochondria were investigated in the tumor cells through a transfer generation of the tumor, in those treated with α-peltatin. The data presented indicate that the cells with filamentous or rod-like mitochondria are high in metabolic activity and that the dot-like mitochondria are of general occurrence in the tumor cells being in process of disintegration or in lower metablic activity.
社団法人日本動物学会の論文
1956-07-15