マウスの移植副腎皮質腫瘍の成長におよぼす性ホルモンの影響

概要

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Adrenocortical tumor grafts grew in normal female and gonadectomized male and female mice in a similar fashion, whereas the tumor growth was markedly slower in normal male mice compared with that in the former hosts. Daily injections of 0.5mg testosterone (T) or 25μg-2.5mg testosterone propionate (TP) suppressed the tumor growth in gonadectomized male and female mice. The tumor growth was strongly suppressed in gonadectomized hosts receiving injections of 0.4mg estradiol-17β (E_2). Injections of a 0.5mg daily dose of 5α-dihydrotestosterone or androsterone also suppressed the tumor growth in both gonadectomized male and female hosts, while the growth was not influenced by injections of 1.5mg progesterone in both sexes of gonadectomized hosts. The survival rate was significantly higher in tumor-bearing gonadectomized hosts treated with T, TP or E_2 than in the oil controls.
社団法人日本動物学会の論文
1979-03-25