Effects of Estrogen and Dopamine Agonists on the Expression of Argyrophilic Nucleolar Organizer Regions in Prolactin Cells of Rats
スポンサーリンク
概要
- 論文の詳細を見る
The number of nucleolar organizer regions reflects nuclear and cellular activity, such as the proliferation and differentiation of cells. Prolonged administration of estrogen (E_2) induces the hyperplasia of prolactin (PRL) cells and the development of PRL-secreting pituitary tumors in rats. Dopamine agonists are known to reduce the effects of E_2 treatement. The purpose of this study was to investigate whether the changes of argyrophilic nucleolar organizer regions (AgNORs) in PRL cells are related to circulating levels of PRL or to the proliferative activity of PRL cells during the administration of stimulatory (E_2) or inhibitory (dopamine agonist) treatment in rats. E_2 increased the size and number of AgNORs per nuclear profile in PRL cells in rats. Bromocriptine and cabergoline, which are dopamine agonists, each reduced the number and size of AgNORs in PRL cells treated with E_2 for 10 weeks. In rats treated with E_2 alone or dopamine agonists followed by E_2, the number and size of AgNORs were correlated more closely with serum levels of PRL than with the proliferative activity of PRL cells. However, neither the number nor size of AgNORs in PRL cells was related with these parameters in different ages of the control. The number and size of AgNORs may be useful in evaluating the secretory activity of pituitary cells during the administration of stimulatory or inhibitory agents.
- 社団法人日本動物学会の論文
著者
-
Kawamoto Keiichi
Department Of Biology Faculty Of Science Toyama University
-
Tamai Kazuhiro
Department of Biology, Faculty of Science, Toyama University
-
Tamai Kazuhiro
Department Of Biology Faculty Of Science Toyama University
関連論文
- NOVEL HAMSTER HYPOTHALAMIC LPXRFA PEPTIDES STIMULATE LH RELEASE(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- IDENTIFICATION OF NOVEL HAMSTER HYPOTHALAMIC LPXRFa PEPTIDES STIMULATING LH RELEASE
- MELATONIN ACTION ON GnIH-LILKE IMMUNOREACTIVE NEURONS IN THE SIBERIAN HAMSTER (PHODOPUS SUNGORUS)(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- EFFECTS OF PHOTOPERIODS ON GnIH-RELATED PEPTIDE-IMMUNOREACTIVE (IR) NEURONS IN THE HAMSTER BRAIN(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- GNIH-RELATED PEPTIDE (LPXRFAMIDE)-IMMUNOREACTIVE NEURONS IN THE HAMSTER BRAIN : THEIR DISTRIBUTION IN THE BRAIN, PHOTOPERIODIC EFFECTS AND INTERACTION WITH THE GNRH NEURONAL SYSTEM
- Effect of Cabergoline, a Dopamine Agonist, on Estrogen-Induced Rat Pituitary Tumors : In Vitro Culture Studies
- Characteristics of Prolactin secretion in Normal and Estrogen-Treated Pituitaries of Rats at the Single Cell Level: Analysis by Reverse Hemolytic Plaque Assay
- Responses of Pineocytoma to Radiation Therapy and Chemotherapy : Report of Two Cases
- Secretion of Growth Hormone (GH) -Releasing Hormone by GH-Producing Pituitary Adenoma Assessed by Cell Immunoblot Analysisi
- EFFECT OF DAYLENGTH AND SEX DIFFERENCE ON PHEROMONE RECEIPT AND TRANSMISSION IN THE VOMERONASAL OF SIBERIAN HAMSTERS (Phodopus Sungorus) : TRANSMISSION SYSTEM AND SEX DIFFERENCES
- Changes in the Gonadotropin-Releasing Hormone(GnRH) Neuronal System during the Annual Reproductive Cycle of the Horseshoe Bat, Rhinolophus ferrumequinum(Endocrinology)
- PHOTOPERIODIC EFFECTS ON THE RESPONSIVENESS OF FEMALE HAMSTERS TO MALE PHEROMONES(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- THE RESPONSIVENESS TO MALE-DERIVED PHEROMONES OF FEMALE HAMSTERS KEPT UNDER DIFFERENT PHOTOPERIODS
- Multiple Oligodendroglioma : Case Report
- CHARACTERIZATION OF GONADOTROPHS IN THE PARS TUBERALIS OF HAMSTERS(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- PROPERTIES OF FOLLICLE-STIMULATING HORMONE RECEPTORS DURING ANNUAL REPRODUCTIVE CYCLE IN THE TESTIS OF THE HORSESHOE BAT
- Effects of Estrogen and Dopamine Agonists on the Expression of Argyrophilic Nucleolar Organizer Regions in Prolactin Cells of Rats
- Endocrine Control of the Reproductive Activity in Hibernating Bats
- Development of Pt/MgO(100) Buffer Layers for Orientation Control of Perovskite Oxide Thin Films