Neuron-like morphology expressed by perinatal rat C-cells in vitro

概要

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Thyroid C-cells (calcitonin-producing cells) are endocrine derivatives of the neural crest. The morphological plasticity of rat C-cells was examined under cell culture. In a primary culture of perinatal rat thyroid glands, a small number of C-cells were found to extrude neurite-like processes, some of which reached 350pm in length. The processes frequently branched and had varicosity-like structures. The processes were intensely stained with anti-α-tubulin antibody, suggesting that microtubular cytoskeleton participated in their elongation and maintenance. In primary cultures of C-cells derived from postnatal rats at day 2 or later, no neurite-like processes were observed . These findings suggest that at least some C-cells in the perinatal rat thyroid retain the potential to extrude neurite-like processes, as do chromaffin cells in adrenal medulla, another type of crest-derived endocrine cell.
社団法人日本動物学会の論文
1994-06-15