Developmental Changes in Pteridine Biosynthesis in the Toad, Bufo vulgaris
スポンサーリンク
概要
- 論文の詳細を見る
The presence of blue-violet fluorescent pteridines, neopterin, biopterin, pterin and isoxanthopterin, in a toad tadpole in the various development stages was determined by HPLC with fluorimetric detection. Changes in the activities of pteridine- synthesizing enzymes, GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase and sepiapterin reductase, were also investigated. In contrast to an older report by Hama, neopterin was already found in the tadpole larval stage, as well as in the young adult stage. Also, biopterin was found not only in the tadpole larval stage but also in the young adult stage. Neopterin constitutes the major portion of the pteridines of the animal and biopterin makes up the minor one throughout the whole development stage. In spite of the high content level of neopterin in the young adult stage, the activity of GTP cyclohydrolase I, which produces dihydroneopterin triphosphate, declined ; and the activity of 6-pyruvoyl-tetrahydropterin synthase, which metabolizes dihydroneopterin triphosphate as a substrate , rose in the same stage.
- 1994-06-15
著者
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Nakagoshi Motoko
Biological Laboratry, Center for Natural Science, Kitasato University
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Nakagoshi Motoko
Biological Lab. Center For Natural Science Kitasato University
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TAKIKAWA Shin-Ichiro
Biological Laboratory, Kitasato University
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Nakagoshi M
Kitasato Univ. Kanagawa Jpn
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Takikawa Shin-ichiro
Biological Laboratory Kitasato University
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Takikawa S
Biological Laboratory Kitasato University
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