Effectiveness of Metoclopramide, Domperidone and Ondansetron as Anti-emetics in the Amphibian, Xenopus laevis

スポンサーリンク

概要

• 論文の詳細を見る

• We examined the effectiveness of three anti-emetic agents-metoclopramide, domperidone (both dopamine antagonists) and ondansetron (a 5HT_3 receptor antagonist)-in the frog Xenopus laevis. Apomorphine and cisplatin were used to induce emesis. All three anti-emetics significantly retarded emesis when induced by apomorphine. The drugs, however, were not effective against cisplatin induced emesis in the limited dosage range that we examined. Paradoxically, both metoclopramide and domperidone themselves induced vomiting in some frog specimens at dosages where they retarded apomorphine-induced emesis in others. Xenopus laevis appears to be particularly sensitive to a variety of emetic challenges. Our results suggest that neural mechanisms involved in the control of emesis in amphibians and mammals are similar, although there are differences in the sensitivity of frogs and mammals to emetic and anti-emetic agents. Since Xenopus is an easy frog to maintain and breed in captivity, it may be valuable as an alternative model to mammals in the pharmaceutical search for effective anti-emetic agents.

• 社団法人日本動物学会の論文
• 1994-06-15

著者

• Naitoh Tomio

  Department Of Biological Science Faculty Og Life And Environmental Science Shimane University

• Naitoh Tomio

  Department Of Biological Science Shimane University

• Wassersug J.

  Department Of Anatomy And Neurobiology Dalhousie University

• Wassersug J.

  Department Of Biology Shimane University

• Wassersug Richard

  Department Of Anatomy & Neurobiology Dalhousie University

• Matuura Motoko

  Department of Biology, Shimane University,

• Matuura Motoko

  Department Of Biology Shimane University

関連論文

• STEREOSCOPIC IMAGES IN THE SMOOTH MUSCLE FIBERS OF THE SMALL AND LARGE INTESTINES IN TADPOLES (RHACOPHORUS OWSTONl) DURING METAMORPHOSIS(Cell Biology and Morphology & Developmental Biology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological
• COMPARATIVE HISTOLOGICAL STUDIES OF THE LIVERS IN AMPHIBIANS ASSOCIATED WITH THEIR DIVERGED MODE OF LIVING(Cell Biology and Morphology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
• Amphibian Amplexus in Microgravity
• Life History of Amphibians and Gravity
• The Frog in Space (FRIS) Experiment Onboard Space Station Mir: Final Report and Follow-on Studies
• The Frog in Space(FRIS)Experiment Onboard Space Station Mir:Final Report and Follow-on Studies (特集:日本の宇宙生物学実験)
• The Behavioral Reactions of a Snake and a Turtle to Abrupt Decreases in Gravity
• Tissue sensitivity to thyroid hormone in athyroid Xenopus laevis larvae
• Behavioral Reactions of the Bat Carollia perspicillata to Abrupt Changes in Gravity
• Effectiveness of Metoclopramide, Domperidone and Ondansetron as Anti-emetics in the Amphibian, Xenopus laevis
• Startle Response and Turning Bias in Microhyla Tadpoles(Behavior Biology)
• Accumulation of Urine after Denervation of Abdominal Walls in Bullfrogs
• Adaptation of a Common Freshwater Goby, Yoshinobori, Rhinogobius brunneus Temminck et Schlegel to Various Backgrounds Including Those Containing Different Sizes of Black and White Checkerboard Squares(Physiology)
• Movements in the Alimentary Canal of an Intact Oligochaeta, Eramimizu, Branchiura sowerbyi BEDDARD

もっと見る 閉じる

スポンサーリンク