Angiotensin II Receptor Subtypes : Their Distribution, Signaling Pathways, and Physiological Functions
スポンサーリンク
概要
- 論文の詳細を見る
Angiotensin II (Ang II) exhibits a variety of physiological actions, related mainly to the regulation of blood pressure and fluid osmolarity. Recent identification of the multiple types of the Ang II receptors raises the possibility that Ang II has other unknown functions. The Ang II type 1 receptor (AT_1) mediates most of the known physiological functions of Ang II, whereas the type 2 receptor (AT_2)-mediated functions remain unclear, AT_2 is particularly interesting because it is expressed abundantly in fetal tissues and in cells undergoing apoptosis. AT_1 and AT_2 exhibit unique signaling pathways among the superfamily of seven membrane-spanning receptors: i.e. the coupling of AT_1 to the Janus kinase-signal transducers and activators of transcription pathway and the coupling of AT_2 to phosphatase activation. Also, the two subtypes induce several opposite intracellular events. AT_1 mediates activation of Ca^<2+> channels and inhibition of K^+ channels, whereas AT_2 induces inhibition of Ca^<2+> channels and activation of K^+ channels. Therefore, it is of great importance to compare the two receptor subtypes with respect to their distribution, signaling pathways, and physiological functions.
- 社団法人日本動物学会の論文
- 1996-10-15
著者
-
Ohnishi Junji
Division of Biological Sciences, Graduate School of Science, Hokkaido University
-
Miyazaki Hitoshi
Institute of Applied Biochemistry, University of Tsukuba
-
Miyazaki H
Univ. Tsukuba Ibaraki
-
Ohnishi Junji
Division Of Biological Science Graduate School Of Science Hokkaido University
-
Shibata Takeshi
Institute of Applied Biochemistry, Gene Experiment Center, University of Tsukuba
-
Miyazaki Hitoshi
Univ. Tsukuba Tsukuba Jpn
-
Miyazaki Hitoshi
Institute of Applied Biochemistry, Gene Experiment Center, University of Tsukuba
関連論文
- Hypotensive Effects of an Angiotensin II Type 1 Receptor Antagonist Differ between Exercised and Sedentary Rats Aged from 4 to 19 Weeks
- P680 PHYSICAL EXERCISE PROMOTES THE INHIBITORY EFFECT OF THE ANGIOTENSIN II TYPE 1 RECEPTOR ANTAGONIST TCV-116 ON SYSTOLIC BLOOD PRESSURE IN NORMAL RATS.
- Exercise-Induced Change in β-Adrenergic Receptor Number in Lymphocytes from Trained and Untrained Men
- Molecular Mechanism of Follicle Rupture during Ovulation
- Occurrence of a Latent Serine Protease in the Follicular Fluid of Porcine Ovary
- Proteolytic Activation of Single-chain Tissue-type Plasminogen Activator by Protease/α_2-Macroglobulin Complex Isolated from Human Ovarian Follicular Fluid(Endocrinology)
- 0804 EXPRESSION OF ENDOTHELIN-1 mRNA IN THE HEART OF PATHOLOGICAL HYPERTROPHY OR PHYSIOLOGICAL HYPERTROPHY
- Cardiac Hypertrophy by Hypertension and Exercise Training Exhibits Different Gene Expression of Enzymes in Energy Metabolism
- Protein Tyrosine Phosphatase PTPεM Induces Apoptosis in Porcine Ovarian Granulosa Cells
- Correlation of Mitogen-Activated Protein Kinase Activities with Cell Survival and Apoptosis in Porcine Granulosa Cells(Reproductive Biology)
- Angiotensin II Receptor Subtypes : Their Distribution, Signaling Pathways, and Physiological Functions
- Quantum force due to distinct boundary conditions(Quantum Field Theories: Fundamental Problems and Applications)
- Proteolytic Activation of Tissue-Type Plasminogen Activator by the Culture Media of Mouse Cancer Cells
- Regulation of Ovarian Renin Gene Expression by Follicle Stimulationg Hormone and Estrogen
- Expression of mRNA of Key Enzymes in Energy Metabolism in the Heart of Physiological Hypertrophy or Pathological Hypertrophy
- Conditioned switching of matrix metalloproteinase-23 expression during the ovarian follicular development