Spontaneous Mutations of Trichlorfon Resistance in the Nematode, Caenorhabditis elegans : Genetics

概要

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Spontaneous trichlorfon-resistant mutations were isolated in Caenorhabditis elegans var. Bergerac and its derived mutator strains. Of these, six uncoordinated mutations were assigned by complementation analyses to the unc-13(cn490), unc-17(cn355), unc-18(cn347), unc-10(cn257), unc-3(cn4146) and unc-41(cn252) genes. Resistance of these mutations to acetylcholinesterase (AChE) inhibitors is partial, with the extent dependent on the mutations. These mutations fall into two classes based on acetylcholine (ACh) levels, that is, the normal ACh levels in unc-10 and unc-3 mutations and the abnormally high ACh levels in unc-13, unc-17, unc-41 and unc-18 mutations. Mutations in the latter gene groups are also accompanied by growth retardation and small body size in adulthood. Double mutants were constructed between the six trichlorfon-resistant strains together with the cha-1-unc-17 complex gene alleles which are also resistant to trichlorfon. All doubles constructed between trichlorfon-resistant strains survived and their properties were studied.
社団法人日本動物学会の論文
1989-08-15