Modulation of HSP70 and HSP90 Expression by Sodium Salicylate and Aspirin in Fish Cell Line CHSE-214 : Biochemistry

スポンサーリンク

概要

• 論文の詳細を見る

• Nonsteroidal anti-inflammatory drugs (NSAlDs) such as sodium salicylate, aspirin and indomethacin have been reported to activate the heat shock transcription factor (HSF) without enhancing the expression of the heat shock proteins (HSPs). We investigated the effects of NSAlDs on the heat shockinduced HSP expression in fish cell line CHSE-214. Here we reveal that in CHSE-214 cells, co-exposure to sodium salicylate/aspirin and heat shock (24℃) enhances and prolongs the heat shock-induced HSP70 expression presumably through activation of the HSF. In contrast, the heat shock-induced HSP90 expression was inhibited by these NSAIDs. Thus, sodium salicylate and aspirin are likely to exert different effects on the heat shock-induced HSP70 and HSP9O expression. Indomethacin, another cyclooxygenase inhibitor, had no stimulatory or inhibitory effects on the heat shock-induced HSP70 and 90 expression, thereby indicating that sodium salicylate and aspirin may modulate the heat shock response via pathways not involving cyclooxygenase. Since anti-oxidants could inhibit the heat shock-induced HSP70 expression, the stimulatory effects of sodium salicylate and aspirin on the HSP70 expression are not likely due to their ability to act as anti-oxidants. Additionally, sodium salicylate and aspirin could exert synergistic effects on the HSP70 expression at lower temperatures (20-22℃) that did not induce the HSP70 expression.

• 社団法人日本動物学会の論文
• 2000-12-10

著者

• Kim Han

  Department of Orthodontics, Osaka Dental University

• Kang Ho

  Department Of Molecular Biology College Of Natural Sciences Pusan National University

• Kim Han

  Department Of Biotechnology Hoseo University

• Koo Hyun

  Department Of Molecular Biology College Of Natural Sciences Pusan National University

• Moon Dae

  Deep-sea Fisheries Division National Fisheries Research And Developmet Institute

• KANG Kwang

  Department of Physics, Gyeongsang National University

• Kang Kwang

  Department Of Molecular Biology College Of Natural Sciences Pusan National University

• Kim Han

  Department Of Molecular Biology College Of Natural Sciences Pusan National University

• Oh Su

  Department Of Molecular Biology College Of Natural Sciences Pusan National University

• Kang Ho

  Department Of Internal Medicine Chonnam National University Medical School

• Koo Hyun

  Department Of Materials Science And Engineering Pohang University Of Science And Technology (postech

• Koo Hyun

  Department Of Biochemistry College Of Science Protein Network Research Center Yonsei University

• Kim Han

  Department Of Biochemistry College Of Life Science And Biotechnology Yonsei University

• KANG Ho

  Department of Dermatology, Hanyang University College of Medicine

関連論文

• Evaluation of 3D-CT stereotaxic images for lateral cephalometric analysis
• Importance of head positioning in cephalometric analysis of 3 D-CT stereotaxic images
• Evaluation of 3D-CT stereotaxic imaging for frontal cephalometric analysis
• Development and Industry of Health Functional Food in Korea
• Endoprosthetic Reconstruction after Resection of Primary Bone Tumors
• Acute Onset of Steroid Psychosis with Very Low Dose of Prednisolone in Sheehan's Syndrome
• NK/T-Cell Lymphoma Associated with Epstein-Barr Virus in a Patient Infected with Human Immunodeficiency Virus : An Autopsy Case
• A Case of ACTH-Producing Pheochromocytoma Associated with Pregnancy
• Epitaxial Growth of GaN on LaAlO_3(100) Substrate by RF Plasma Assisted Molecular Beam Epitaxy
• Low Dark Current and High-Speed Metal-Semiconductor-Metal Photodetector on Sulfur-Treated InP
• The Detection of Epstein-Barr Virus in the Lesions of Salivary Glands
• Epstein-Barr Virus and CD21 Expression in Gastrointestinal Tumors
• Sauchinone Attenuates Oxidative Stress-Induced Skeletal Muscle Myoblast Damage through the Down-Regulation of Ceramide
• Modulation of HSP70 and HSP90 Expression by Sodium Salicylate and Aspirin in Fish Cell Line CHSE-214 : Biochemistry
• Identification of Heat Shock Protein 90-Associated 84-kDa Phosphoprotein
• Three-Dimensional Kinematic Analysis during Upslope Walking with Different Inclinations by Healthy Adults
• Evidence That a β-1,4-Endoglucanase Secreted by Acetobacter xylinum Plays an Essential Role for the Formation of Cellulose Fiber
• Processing Aggregate Queries with Materialized Views in Data Warehouse Environment(Database)
• Oncogenic Functions of PTK6 are Enhanced by Its Targeting to Plasma Membrane But Abolished by Its Targeting to Nucleus
• IF-1 The usefulness of sputum cytology in screening of lung cancer(Current status of respiratory cytology in Asian countries)
• Precipitation and Growth of Non-metallic Inclusions during Solidification of Steels
• Electrochemical Deoxidation of Molten Steel with Application of an Oxygen Permeable Membrane
• Cloning, Sequencing, and Expression of UDP-Glucose Pyrophosphorylase Gene from Acetobacter xylinum BRC5
• Differences in Plantar Foot Pressure and COP between Flat and Normal Feet During Walking
• Reappraisal of MMR vaccines currently used in Korea
• A Method for Evaluating Composition of Complex Inclusions Comprising Oxides and MnS in Si/Mn/Ti Deoxidized Steels
• Identification of Active Site Residues in Bradyrhizobium japonicum Acetyl-CoA Synthetase
• Comparison of Soft Cervical Collar Versus Cervical-5 Cross-Taping on Cervical Active Range of Motion in Asymptomatic Subjects
• Three New Orcinol-Conjugated Hydrolysable Tannins from the Leaves of Cleyera japonica
• Identification of Active Site Residues in Bradyrhizobium japonicum Acetyl-CoA Synthetase.
• Identification of Heat Shock Protein 90-Associated 84-kDa Phosphoprotein.
• Intravascular myopericytoma : An interesting case of a long-standing large, painful subcutaneous tumor

もっと見る 閉じる

スポンサーリンク