Allosteric Mechanism of Molecular Structural Changes in Opening Transition of the Neuro Chemical Channel on the Excitable Cellular Membrane(Organic-neuro Systems)(<Special Section>Recent Progress of Organic Molecular Electronics)
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概要
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We show a geometric method to compute the Van der Waals factor 1/r^7 between the assemblies of amino acid molecules of the subunits of acetyl choline (abbreviated by Ach: a kind of neuro chemical transmitter) sensitive channel on the post synaptic membrane of the neural system. We induced a analytical geometric formula for the distances between helically arranged ten assemblies of the point amino acid molecules on two interacting membrane perforating poly peptides, M2 helices during channel opening deformation. Detailed geometric parameters have been utilized from reported biophysical measurements. The computed Van der Waals factor decreased rapidly as the slope of the first M2 helix along the central axis of the channel pore has increased. The Van der Waals factor also decreased by an increase in rising angle of the helically arranged amino acids on the M2 helices. The Van der Waals factor increased significantly as the first M2 helix has rotated around the central axis of the channel pore to take an opening position. We discussed the time dependent molecular structural changes of the Ach sensitive channel opening in conjunction with the Allosteric properties of the bio molecules. The molecular mechanism of Ach sensitive channel opening in terms of the Allosteric property may derive from the characteristic helical constitutional nature of the membrane perforating part (M2 helix) of the subunits of the channel molecule.
- 社団法人電子情報通信学会の論文
- 2004-02-01
著者
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Hirayama Hirohumi
Department Of Public Health Asahikawa Medical College
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HIRAYAMA Hirohumi
Department of Public Health , Asahikawa Medical College
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