ベーチェット病眼症状に対する顆粒球除去療法の効果(<特集>白血球系細胞除去療法の最近の展開)

概要

論文の詳細を見る
Behcet's disease (BD) is an inflammatory disorder of unknown etiology with recurrent ocular, vascular, central nervous system, articular, mucocutaneous and gastrointestinl manifestations. Most manifestations of BD are self-limiting, but repeated attacks of uveitis is a major cause of blindness. BD is prevalent and is a major cause of morbidity in most Asian nations, countries along the ancient Silk Road and the Mediterranean basin. Biopsies from active lesions of BD show presence of large numbers of neutrophils in the absence of infection and neutrophils from patients with BD show increased superoxide anion production, enhanced chemotaxis and excessive release of granular enzymes, indicating neutrophil hyperactivity in BD. Therefore, we thought that patients with ocular lesions should respond to therapeutic reduction of neutrophils from peripheral blood by selective adsorption apheresis. In this study, 6 patients were given five sessions of adsorptive neutrophil apheresis, one session/week for 5 consecutive weeks by using an Adacolumn filled with cellulose acetate beads which mainly adsorb neutrophils. The mean number of attacks (±SD) was 2.8±1.2 post-apheresis compared with 5.2±1.7 pre-apheresis (p=0.021) during the preceding 6 months and 3 of 6 patients were free of major attacks. The therapeutic reduction of neutrophils has the potential to cure ocular BD patients.
日本アフェレシス学会の論文
2005-05-31