Toxic epidermal necrolysis(TEN)とアフェレシス

概要

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In this report I summarized the classification, epidemiology, clinical features, causes, pathogenesis, and therapy, including plasmapheresis, of toxic epidermal necrolysis (TEN). An adverse reaction to drugs has been proposed in the pathogenesis of TEN, which is a severe, progressive disease characterized by the sudden onset of skin necrosis. It is frequently associated with systemic involvement, including mucous membrane, and has a high rate mortality. TEN is classified in three types by clinical features : diffuse, Stevens-Johnson, and multiple fixed drug eruption. Although treatment with steroids in an early stage of TEN has often been effective, the therapy is usually based on the removal of offending drugs, fluid replacement, nutritional support, and local management. In these therapies plasmapheresis could be listed in the first line, which method is safe and efficacious, providing rapid cessation.
日本アフェレシス学会の論文
2000-10-31