免疫吸着療法による水疱性類天疱瘡の治療

概要

論文の詳細を見る
Bullous pemphigoid is an autoimmune blistering disease. Antibasement membrane zone antibodies, usually IgG, are thought to play an essential part in the pathogenesis of this disease. We treated 3 intractable patients with pemphigoid by absorbent plasmapheresis using dextran sulfate conjugated cellulose columns with an automated regenerating unit. During a 2-week period, this plasmapheresis was performed 4 to 6 times for each case. Clinical findings, including skin eruptions, were remarkably improved, and the titers of antibasement membrane zone antibodies were decreased after treatment of 1.8 to 4.2 L of plasma. The reduction rates of total IgG were an average 24.7%, 7.4%, and 10.2% in cases 1,2, and 3 respectively. No major side effects were observed during immunoadsorption therapy. These results suggest that the absorbent column is effective for intractable pemphigoid.
日本アフェレシス学会の論文
2000-10-31