HISTOCHEMICAL INVESTIGATION OF HEPATIC GAMMA-GLUTAMYL-TRANSPEPTIDASE OF RATS TREATED WITH HIGH DOSE OF PHENOBARBITAL
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概要
- 論文の詳細を見る
Hepatic gamma-glutamyl transpeptidase (GGTP) induced by the administration of 0.2% phenobarbital (PB) for 20 weeks in rats was investigated histochemically. By the PB treatment, centrolobular and midzonal hepatocytes became hypertrophic and periportal hepatocytes proliferated when examined on sections stained with hematoxylin and eosin. Histochemically, GGTP activity was demonstrated only in ductular structure and in bile canaliculi of occasional periportal hepatocytes of non-treated rats, whereas with PB treatment, the majority of proliferated periportal hepatocytes showed markedly increased activity of GGTP in bile canaliculi. Centrolobular and midzonal hepatocytes did not show any activity of GGTP, even with the PB treatment. Thus, the induction of GGTP by PB was only evident in the periportal hepatocytes.
- 日本組織細胞化学会の論文
著者
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MOCHIZUKI Yohichi
Department of Pathology, Cancer Research Institute, Sapporo Medical University School of Medicine
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Mochizuki Yohichi
Department Of Pathology Cancer Research Institute
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Mochizuki Yohichi
Department Of Pathology Cancer Research Institute Sapporo Medical College
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FURUKAWA KAZUNORI
Department of Pathology, Cancer Research Institute, Sapporo Medical College
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Furukawa Kazunori
Department Of Pathology Cancer Research Institute Sapporo Medical College
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