UPTAKE OF ^3H-GABA BY THE PURKINJE CELLS OF THE RAT EMBRYO
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The uptake of ^3H-GABA by the Purkinje cells in the rat embryo was examined by light and electron microscopic autoradiography. The developing Purkinje cells became first labelled with ^3H-GABA at E-18 when they began to form the primordium of the Purkinje cell layer, and continued to be labelled until E-22 (at term). From E-18 to E-20 most of the Purkinje cells were heavily labelled, but at E-21 and E-22 the Purkinje cells situated at the top of the cerebellar gyri were heavily labelled while those situated at the bottom of the cerebellar sulci were not labelled. Silver grains on the labelled Purkinje cells were distributed on both the nucleus and the cytoplasm. At E-22 a few unlabelled axon terminals on the labelled Purkinje cell soma and also a few labelled glial processes in the Purkinje cell layer were first detected. Throughout the stages examined no silver grains were found on the external granular layer, on the molecular layer and on the intercellular spaces of the Purkinje cell layer as well as of the mantle layer. These findings indicate that the developing Purkinje cells in rat embryo possess an ability of ^3H-GABA uptake before synapses and/or glial wrapping around their soma are formed.
- 日本組織細胞化学会の論文
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