AN IMMUNOHISTOLOGICAL STUDY OF DISTRIBUTION OF BETA-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN (hCG-β) IN TROPHOBLAST-LIKE CELLS IN THE LUNG TUMOR

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Two patients with hCG-producing tumors were investigated. One was a lung tumor in a postmenopausal patient and the other a primary choriocarcinoma of the uterus. Tissue of the liver in the former and the circulating blood of both patients were also investigated. The present paper describes the distribution of hCG among those tissues in order to make a histological characterization of trophoblast-like cells found in the lung at autopsy as to whether they compose primary or metastatic choriocarcinoma including trophoblastic differentiation of carcinoma cells. The authors performed an immunohistological detection of tissue hCG using beta-subunit of hCG (hCG-β) obtained from normal pregnant women. There was no dissimilarity of intracytoplasmic distribution between trophoblast-like cells and syncytial trophoblasts in uterine choriocarcinoma, which implies that hCG-β from normal pregnant women seems not to be helpful to cytological differentiation for hCG-producing tumors because of the suspected heterogeneity of hCG-β due to its origin. Further examination is required to submit an acceptable significance of the findings that hCG-β is demonstrated in not only cells enclosed in pulmonary alveoli or hepatic cells but also leucocytes in circulating blood.
日本組織細胞化学会の論文