ON MORPHOGENESIS OF THE ACID PHOSPHATASE ACTIVITY; ITS SIGNIFICANCE IN ADRENAL PIGMENTS FORMATION OF LANOLIN-TREATED RABBITS OR AGED RATS AND IN DEXTRAN STORAGE OF RAT LYMPH NODE MACROPHAGES (PHYSIOLOGY AND PATHOLOGY OF LYSOSOMES)

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The morphogenesis of ACPase activity was observed in the following experimental materials: 1) The parenchymal cells and macrophages of the adrenal cortex of cholesterol-treated rabbits. 2) The same cells of the adrenal cortex of aged rats. 3) The macrophages of the mesenteric lymph nodes of rats having received a large amount of macromolecular dextran. In these experiments, (1) the increase or occurrence of activity as a function of biological significance was difficult to detect in cells displaying a degenerative process, notwithstanding their apparent histochemical stainability as "ceroid pigment", and (2) in the macrophages, under the present experimental conditions, the increase or occurrence of activity could be observed in more or less extensive areas of the cytoplasm, especially on the membrane system sharply demarcating these areas; the so-called residual bodies were seen to be produced there in groups concomitant with the appearance of their histochemical stainability as ceroid pigment. This membrane system, judging by the evidence given by the plane u1trastructural pictures, seems to be intimately related to the smooth or rough ER system.
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