ULTRASTRUCTURE AND CYTOCHEMICAL STUDIES ON HUMAN TUMORS SECRETING CATECHOLAMINES (SYMPOSIUM ON HISTOCHEMISTRY AND CYTOCHEMISTRY OF NEUROTRANSMITTERS AND ITS CLINICAL APPLICATION)
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概要
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Correlative ultrastructural and biochemical studies on 38 human neurogenic tumors, adrenal medulla and sympathetic ganglions revealed the following findings: Firstly, this group of tumors has an ability to synthesize catecholamines (CA). Secondly, the ultrastructure of tumors resembles that of their normal tissue counterparts of various differentiations. Multidirectional differentiation in the tumor is common. Thirdly, the CA granules in pheochromocytoma and paraganglioma were similar to those in adrenal medulla of human and rodent. Large cored, small cored and small clear vesicles in all neurogenic tumors resemble those in sympathetic ganglions and nerve endings. Granular resemblance suggested the similarity of CA storage in tumors and in control tissues. Fourthly, double fixation with the use of aldehyde and osmium revealed that the human adrenal medulla have cells with ellipsoidal granules (E granule) as well as cells with more or less rounded granules (R granule). Fifthly, double fixation revealed that pheochromocytomas have three kinds of cells containing E granules, R granules and granules with dense, peripherally located cores (dp granules) that resemble the NA granules of rat. Sixthly, chemical assay showed the predominance of E and/or dp cells in all the NA dominant tumors. Chemically mixed tumors showed a mixed type of dp/E and R cells. One A dominant tumor was R dominant. This suggests that E and dp granules contain NA and that R granules contain A in pheochromocytomas. The E cells in human adrenal medulla also appear to be of the NA storing type.
- 日本組織細胞化学会の論文
著者
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Yokoyama Masao
Department Of Environmental Science Faculty Of Agriculture Tokyo University Of Agriculture And Techn
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Yokoyama Masao
Department Of Urology Branch Hospital Faculty Of Medicine The University Of Tokyo
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