HISTOCHEMICAL STUDIES OF HEPATIC HEXOKINASE AND GLUCOSE 6-PHOSPHATASE IN CHRONIC LIVER DISEASES

スポンサーリンク

概要

• 論文の詳細を見る

• Two rate limiting enzymes of glycolysis and gluconeogenesis, i.e, lowKm hexokinase (HK) and glucose 6-phosphatase (G6Pase), respectively, in liver tissues of patients with liver diseases, including acute hepatitis (convalescent stage), chronic hepatitis (active and inactive forms) and chronic hepatitis with sublobular hepatic necrosis and cirrhosis of the liver, were demonstrated histochemically. Generally, an intense staining of HK and a weak staining of G6Pase were observed in the degenerated hepatic cells in the lobule. In chronic hepatitis, active form, the HK activity was increased in the whole lobule with an emphasis in the central area, whereas the G6Pase activity was decreased in the central area. Chronic hepatitis with sublobular hepatic necrosis, which has been assumed to progress rapidly into the cirrhosis of the liver, was characterized by an uneven distribution of HK and G6Pase within the hepatic lobule; the activity of the former being increased and the latter decreased at the site of hepatic cell injuries. In cirrhosis of the liver, the HK activity was increased and G6Pase activity was retained well in the well defined nodule, whereas the latter was significantly decreased in the nodule of swollen and irregular hepatic cells with marked infiltration of round cells in the connective tissue.

• 日本組織細胞化学会の論文

著者

• Aoe Hajime

  The First Department Of Internal Medicine Okayama University Medical School

関連論文

• HISTOCHEMICAL DEMONSTRATION OF FRUCTOSE 1,6-DIPHOSPHATASE IN RAT LIVER USING NITRO-BLUE TETRAZOLIUM
• Histochemical Demonstration of Human Liver Hexokinase
• HISTOCHEMICAL DEMONSTRATION OF HUMAN LIVER HEXOKINASE USING NITRO-BLUE TETRAZOLIUM
• Histochemical Demonstration of Rat Liver Fructose-1,6-diphosphatase
• HISTOCHEMICAL STUDIES OF HEPATIC HEXOKINASE AND GLUCOSE 6-PHOSPHATASE IN CHRONIC LIVER DISEASES

スポンサーリンク