SECRETION OF THE CONTENT OF GRANULES AND ITS RELATIONSHIP TO THE ACID PHOSPHATASE REACTION IN REGENERATING RAT PERITONEAL MAST CELLS

概要

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With an intraperitoneal injection of distilled water into the peritoneal cavity of rats, the peritoneal mast cells disappeared completely. Regenerating mast cells were studied two weeks after the injection. In these mast cells there was smooth transition in the structures of granules from a compact through a reticular granule to a granule with residual materials. This sequence was interpreted as a secretion process. This process was also observed in a few mast cells of control animals, but very active in the regenerating mast cells. Acid phosphatase activity of the mast cells in the control rats was observed in the Golgi apparatus and intergranular cytoplasmic matrix. No reaction was found in the granules except for a few granules of a few mast cells. A distinct positive reaction was observed in many granules of many regenerating mast cells. Acid phosphatase positive granules did not have a compact and homogeneous but a reticular structure in the regenerating mast cells as well as in a few mast cells of control animals. An intimate relationship observed between the transition of structures of granules and the intensities of their acid phosphatase reaction suggests that the acid phosphatase or enzymes activated simultaneously with the acid phosphatase play an important role in the degradation of the content of granules which would be secreted.
日本組織細胞化学会の論文
1974-00-00