SULFHYDRYL LEVELS IN PIGMENT SYNTHESIZING AND NON-PIGMENT SYNTHESIZING SKINS OF RODENTS

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Sulfhydryl groups (-SH) are one of the most potent inhibitors of melanogenesis (Flesch, 1949; Flesch and Goldstone, 1950), and are believed to be one of the causes leading to leucoderma in human beings (Lerner and Fitzpatrick, 1950). Histochemical and biochemical studies of -SH groupswere therefore carried out in black, brown and white skin regions of the guinea pig and the skins of the albino and black rats. In general, the albino rat skin showed the highest concentration of -SH groups followed by the white skin region of the guinea pig. The black skin region of the guinea pig and the black rat skin had moderate amounts of -SH groups, whereas the brown skin region of the guinea pig showed the lowest concentrations.Histochemical localization of -SH revealed intense staining in the hair bulb of the white rat and the white skin region of the guinea pig. The black rat skin as well as the other skin areas of the guinea pig showed lesser staining of -SH groups. The importance of -SH groups in melanogenesis and keratinization are discussed.
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