Amyloid β Peptides and Presenilins in the Pathogenesis of Alzheimer's Disease (Symposium VIIHistochemistry for Neuroscience Research)

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概要

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• Amyloid β peptides, especially those ending at the 42nd residue (Aβ42), is the initially and predominantly deposited Aβ species in the brains of patients with Alzheimer's disease and Down's syndrome. The pathogenetic significance of overproduction and/or deposition of Aβ42 is highlighted because mutations in multiple different genes responsible for early-onset familial Alzheimer's disease, i.e. those in βAPP, presenilin 1 and 2 genes,led to an increase in the secretion and depositidn of Aβ42.

著者

• Iwatsubo Takeshi

  Department Of Neuropathology And Neuroscience Graduate School Of Pharmaceutical Sciences University

• Iwatsubo Takeshi

  東京大学 薬学系研究科臨床薬学教室

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