急性循環不全から多臓器不全への進展(<特集>多臓器不全とアフェレシス)

概要

論文の詳細を見る
Acute circulation failure includes bleeding, cardiogenic, infective and neurogenic shock. This sudden decrease of blood pressure causes organ deficiency. Therefore to effect a breakaway from an initial state of shock is to grasp a survival key. In this review, I consider development from shock to organ dysfunction relation to blood purification therapies. A representative situation of shock is ischemia and reperfusion injury. The main mechanisms of this disorder are injury to tissue oxygenation and microcirculation. Several mediators such as inflammatory cytokine and cannabinoids contribute to this shock. The removal by blood purification therapies of these mediators offers hope, but still an essential treatment has not been developed.
日本アフェレシス学会の論文
2004-02-29