サイトカインによる創傷治癒を考慮したアフェレシス(<特集>多臓器不全とアフェレシス)

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Abnormally increased proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α) or interleukin-6 (IL-6) cause shock, multiple organ failures, and sometimes death. In order to remove lethal cytokines, experimental and clinical studies about using antibody therapy or removal by blood purification were promoted. In Japan, blood purification treatment has been performed and because the outcome was excellent it was accepted widely for clinical application. Recent advances in molecular biology have greatly expanded our understanding of the biological processes involved in wound healing and tissue regeneration. Wound healing is a complex process requiring the collaborative efforts of many different kind of cytokines and details of control signals are beginning to emerge. Such cytokines as TNF-α or IL-6 are surely lethal but they are also necessary for wound healing. The time for a review for cytokines has come. Continuous hemodiafiltration (CHDF) removes the crucial cytokines but it also removes cytokines which may play important roles in the wound healing and regeneration process. We have therefore developed a blood purification treatment which is carried out intermediately and the outcomes of which reached satisfactory levels. It is suggested that the new procedure of intermittent blood purification could be acceptable to patients who suffer trauma or surgery and need wound healing. I described the cytokines connected with wound healing and new blood purification treatment in consideration of holding down the influence on wound healing.
日本アフェレシス学会の論文
2004-02-29

サイトカインによる創傷治癒を考慮したアフェレシス(<特集>多臓器不全とアフェレシス)

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