Receptors for Insulin-like Growth Factor (IGF)-II/cation-independent Mannose-6-phosphate Are Present in Mouse Neurons and Influenced by IGF-II Treatment

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概要

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• We investigated the cellular and subcellular localization of IGF-II receptors in the adult mouse central nervous system (CNS). The IGF-II receptor and the cation-independent (Cl) mannose-6-phosphate (M6P) receptor are identical. Immunohistochemistry demonstrated that IGF-II/CI-M6P receptor immunoreactivity was mostly restricted to middle- to large-sized neurons throughout the CNS. A small number of glial cells were weakly to moderately labeled. IGF-II/CI-M6P receptor immunoreactivity was largely recognized within endosome-lysosomal structures in the neurons by immuno-electron microscopy (EM) of the CNS tissues. More intense labeling was observed in larger neurons that included more abundant endosome-lysosomal structures, indicating that IGF-II/CI-M6P receptor immunoreactivity reflects the endosome-lysosomal activity specifically present in neurons. These results are consistent with the general assumption that IGF-II/CI-M6P receptors are involved in sorting lysosomal enzymes within cells. IGF-II/CI-M6P receptors also endo-cytose secreted IGF-II and M6P-containing glycoproteins as scavenger receptors. Furthermore, it has been reported that they are involved in the development of transmembrane IGF-II signals. Therefore, we next tried to determine if they are expressed on the cell surface of primary cultured cortical neurons. By immunofluorescence and immuno-EM, particularly by immuno-scanning EM, expression of IGF-II/CI-M6P receptors was demonstrated in the neuronal cell surface in response to IGF-II treatment.

• 日本組織細胞化学会の論文

著者

• SHIRABE Teruo

  Departments of Neuropathology, Kawasaki Medical School

• Shirabe T

  Department Of Neuropathology Kawasaki Medical School

• Shirabe Teruo

  Department Of Neuropathology Kawasaki Medical School

• FUSHIMI Shigeko

  Department of Public Health, Kawasaki Medical School

• Fushimi S

  Department Of Neuropathology Kawasaki Medical School

• Fushimi Shigeko

  Department Of Neuropathology Kawasaki Medical School

• KONISHI Yoshihiro

  Department of Neuropathology, Kawasaki Medical School

• Konishi Yoshihiro

  川崎医科大学 神経病理学

• Konishi Yoshihiro

  Department Of Neuropathology Kawasaki Medical School

• Konishi Yoshihiro

  Department of Clinical Research, Nishi-tottori National Hospital

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